Medicine

Progressing ASO therapies coming from development to application

.Contending passions.R.S., M.S., H.G. and also A.A.R. are actually planners of the 1M1M initiative. H.G. and also A.A.R. are actually board of directors participants and also R.S., M.S. and A.A.R. are participants of the scientific advising committee of N1C. A.A.R. reveals work through LUMC, which possesses licenses on exon-skipping innovation, some of which has actually been actually licensed to BioMarin and ultimately sublicensed to Sarepta. As co-inventor of a few of these licenses, A.A.R. was qualified to an allotment of royalties. A.A.R. better discloses acting as ad hoc expert for PTC Therapies, Sarepta Therapeutics, Regenxbio, Dyne Therapies, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and also Astra Zeneca. Before 5 years, A.A.R. also did ad hoc speaking to for Alpha Anomeric. A.A.R. also mentions membership of the clinical advisory boards of Eisai, Hybridize Therapeutics, Silence Therapies, Sarepta Rehabs, Sapreme and also Mitorx. Previously 5 years, A.A.R. was actually also a medical board of advisers participant for ProQR. Reimbursement for A.A.R. u00e2 s consulting as well as urging tasks is actually paid out to LUMC. In the past 5 years, LUMC additionally obtained audio speaker honoraria coming from PTC Therapeutics, Alnylam Netherlands, Italfarmaco and Pfizer as well as cashing for deal research from Sapreme, Eisai, Galapagos, Synaffix as well as Alpha Anomeric. Task financing is actually obtained from Sarepta Rehabs as well as Entrada using unconstrained gives. H.G. possesses nothing to disclose in relation to the subject matters covered within this composition. Previously 5 years, he has actually also acquired working as a consultant gratuity coming from UCB. M.S. got consultancy gratuity coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and Solaxa over the last 5 years, all unconnected to the present document. R.S. possesses absolutely nothing to divulge relative to the subject matters covered within this document. She has acquired sound speaker and/or consultancy honoraria or even sponsoring additions from Abbvie, Bial, STADA and also Everpharma previously 5 years.